Array 12 – Pathogen-Associated Immune Reactivity Screen™

Description

The Array 12 Pathogen Antibody Test

The Array 12 looks for IgG antibodies to multiple pathogens that have been linked in literature to autoimmune diseases. The idea is many autoimmune conditions are hypothesised to be triggered by infections via molecular mimicry or chronic inflammation.

What does this test measure?

This panel likely includes:

• EBV (Epstein-Barr Virus) – associated with lupus, MS, etc.
• Coxsackievirus – associated with type 1 diabetes development.
• C. jejuni – linked to Guillain-Barré syndrome (through ganglioside mimicry).
• H. pylori – linked to autoimmune gastritis, thyroid, etc.
• Yersinia – linked to thyroid autoimmunity (Graves’).
• C. trachomatis or others for arthritis maybe.
• Parvovirus B19 – linked to RA.
• C. pneumoniae – possible link to MS.
• Borrelia (Lyme) – sometimes implicated in autoimmunity.
• Candidiasis or molds – some think chronic Candida can provoke autoimmune-like symptoms.
• Possibly HHV-6 (another virus linked to MS).
• Maybe Porphyromonas gingivalis (oral bacteria linked to RA via citrullination).

Who is this test most suitable for?

Patients with a known history of significant exposure to certain infections—such as severe cases of mononucleosis (EBV) or multiple tick bites related to Lyme disease—who are now experiencing autoimmunity; individuals living in moldy environments.

The test is also useful for individuals who suspect they may have chronic infections, such as reactivated Epstein-Barr virus (EBV), which can be associated with chronic fatigue or autoimmune issues. A positive IgG result indicates prior exposure; if the levels are extremely high or rising, it might suggest an ongoing infection. While this test isn’t as direct as testing for the microorganism itself (like with PCR), it provides valuable insights into the immune response related to infection.

Clinical Use

This test serves as a screening tool for persistent infections that may not be immediately apparent but could be contributing to immune dysfunction. In clinical practice, if a patient exhibits autoantibodies or symptoms of autoimmune disorders, this test can indicate whether they have high antibody titers to certain pathogens. High titers could suggest a chronic or past infection that may be exacerbating their autoimmune condition. Treating or managing this infection could potentially improve their symptoms.

Healthcare practitioners may use the results of this test to guide treatment options, such as antivirals or antimicrobials, for patients with autoimmune conditions.