The difference between sensitivity, specificity and positive predictive value in NIPT, and why a high-risk result is often not what it appears.
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What a low-risk or negative NIPT result actually rules out, what it does not, and which parts of antenatal care still matter afterwards.
How NIPT, chorionic villus sampling and amniocentesis differ in what they answer and what they risk, and why they are complementary rather than competing.
What non-invasive prenatal testing screens for, when it can be taken, how accurate it really is and why it is a screening test rather than a diagnosis.
How NIPT performs in twin pregnancies, what a vanishing twin does to the result, and what to tell the laboratory about IVF, donor eggs or surrogacy.
How NIPT determines fetal sex, how accurate it is from 10 weeks, the recognised causes of discordant results, and the clinical reasons it matters.
What fetal fraction is, why a NIPT sample can return no result, what raises and lowers it, and why repeated failure is itself clinically meaningful.
What a high-risk NIPT result means, why it is not a diagnosis, what confirmatory testing involves and how to think through the decisions that follow.
What microdeletion syndromes are, why professional bodies disagree about screening for them, and how to decide whether an expanded NIPT panel suits you.
A complete list of what NIPT screens for, how well it performs for each, and the important conditions it does not cover at all.